We analyze mitochondrial dysfunction
We analyze oxidative stress consequences
We analyze cell metabolic imbalances
We analyze functional metabolism in cell cultures
We analyze cell metabolism in tissue extracts
We analyze cell metabolism in various species
From caenorrhabditis elegans, to flies, mice and humans
WELCOME TO INTEGRACELL
Our CRO develops unique cell metabolism exploration services to better understand cell behavior
OUR PORTFOLIO OF TESTS
INTEGRACELL has developed a fee-for-service based platform for cell metabolism exploration on either in vitro or in vivo models
Cell metabolism comprises a series of daedalian biochemical reactions catalysed by different enzymes, each working with an ultimate goal of either synthetizing complex molecules from simple ones or breaking down complex to simpler ones. INTEGRACELL has developed an extensive repertoire of high-throughput suitable quantitative panel of biological assays allowing an important functional metabolism exploration of several central cell metabolisms.
Oxidative Stress
Enzymatic activities
Cu/Zn Superoxide dismutase (SOD1)
Mn Superoxide dismutase (SOD2)
Catalase (CAT)
Glutathione peroxidase (GPX)
Glutathione reductase (GR)
Glucose 6P dehydrogenase (G6PD)
Glutathione synthase (GSS)
Glutamylcysteinyl synthase (GCLC)
Substrates
Total Glutathione (TG)
Reduced Glutathione (GSH)
Oxidized Glutathione (GSSG)
Malondialdehyde (MDA)
Oxidized LDL (oxLDL)
8-Isoprostane (8-iso-PGF2α)
8-oxo-2′-deoxyguanosine (8-oxo-dG)
Global Antioxidant Tests
DPPH
FRAP
Mitochondrial function
Enzymatic activities
Citrate Synthase (CS)
ETC Complex I (CI)
ETC Complex II (CII)
ETC Complex III (CIII)
ETC Complex IV (CIV)
ATP synthetase Complex V (CV)
Substrates
ATP
Central metabolism
Enzymatic activities
Hexokinase (HK)
Fructose 1,6-diP aldolase (ALDO)
Glyceraldehyde 3-P dehydrogenase (GAPDH)
Pyruvate kinase (PK)
Lactate dehydrogenase (LDH)
Aspartate aminotransferase (ASAT)
Alanine aminotransferase (ALAT)
Gamma-glutamyl peptidase (γGT)
Alkaline phosphatase (ALP)
Glutamate dehydrogenase (GLDH)
Creatine kinase (CK)
Substrates
Lactate
Pyruvate
Malate
Glucose
Acetate
Acetoacetate
Beta-Hydroxybutyrate
Non esterified fatty acids
Triglycerides
Glycerol
Cholesterol
NADPH production
Enzymatic activities
Glucose 6P dehydrogenase (G6PD)
Malic enzyme (ME)
Isocitrate dehydrogenase (IDH)
Substrates
NADP
NADPH
Energy regulation
Insulin
Glucagon
Adiponectin
Leptin
Miscellaneous cell markers
Creatinine
Albumin
Bilirubin
Homocysteine
WE EXPLORE TINY cell METABOLISM VARIATIONS
INTEGRACELL platform allows automated quantification of key metabolic parameters with the highest precision
As it was not possible at present to measure all cell metabolism parameters for metabolism exploration in parallel but successively, hereby generating an unavoidable degradation of the starting material, we have decided to develop new very precise multiparametric means to be able to assess small metabolic variations in the shortest turnaround time. As it is also possible to measure protein (or hemoglobin or DNA…) content in the same sample, we can not only quantified but also compared the different results between us. Therefore, we can unambiguously define enzyme activities ratios, substrates ratios… that allow a true comparison of cell metabolism pathways function at a precise moment.
Spider representation of compared OXPHOS & OS metabolisms at 1g/L and 5g/L glucose in culture of two prostate cell lines
(A: PNT2 and B: LNCaP) 1g/L results are given as reference (100%) and 5g/L values are calculated from the reference
THE FIELDS OUR cell METABOLISM EXPLORATION ADDRESS
INTEGRACELL cell metabolism exploration can help you in different situations
Our simple, flexible and versatile metabolism exploration (compatible with many kind of samples such as cells, tissues, organs, culture media, food, serum, plasma, urine… from different species) enables our customers to get a complete picture of the importance their compounds may have on cellular metabolism either in vitro or in vivo. This will help them to make appropriate decisions on go/no-go steps during discovery.
We can help you to better prove your claims
and compare product efficacy
We can bring you essential data to better select compounds,
then find the best one
We can help you to better select compounds,
then find the best one
We can help you to better understand
the metabolic part of various pathologies
We can help you to analyze what can be maximized
and improved to optimize your wellness or performances
We can help you to better characterize your cellular models
OUR CLIENTS
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