The newly defined quality criteria become a guarantee of quality for its customers.
This analysis should become an integral part of the quality control of each production batch.
In liquid chromatography (HPLC), recurrent problems of reproducibility from one column to another are constantly found. Every manufacturer set up a quality criterion on an essential parameter, which is called theoretical column tray numbers. For each column, they now guarantee, with experimental proof, this number. Unsatisfactory columns are not sold. Since then, thanks to this approach, they have considerably improved their manufacturing processes. Users now buy a more reliable product, they have confidence.
For cellular models, the ideal virtuous circle may be close to that of HPLC. Supplier will sells cells, whose quality has been checked and found to be in line with usual manufacturing values. He gives to customer cell metabolic profile of what he sells, showing its conformity to the usual manufacturing values. The user will buy a more reliable product.
This is what we call « cell metabolic passport« .
Suppliers can then go further and verify how long or how many times the cell lines they sell will keep the metabolic profile they certify.